Practical investigations
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I am going to do an investigation on preparation of aspirin. What method can I use to determine which synthesis is most efficient? Do I (also) have to include the method of recrystallization and thin layer chromatography?
Jenkin writes
When you say 'most efficient', you need to consider both yield and purity.
You certainly have to include your method of recrystallisation, and should be able to calculate your percentage yield after weighing the purified and dried product.
You can usethin layer chromatography to assess teh purity of your product. If you do so you should describe what you do: if possible, include the actual chromatograms (or photographs of them) and their interpretation in your report.
Comparison of recrystallised and unrecrystallised would be helpful, and you could also compare with a commercial sample.
Risk assessment
Before attempting any practical work based on the advice and suggestions on this website, you must do the following. Identify any hazards, assess the risks from these hazards, and then decide appropriate control measures to reduce the risks. You must have these approved by those in authority in your school or college laboratory. Do not rely on what is said on this website.
For further guidance see our tutorial on Risk Assessment.
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updated: 25 February 2005
